A Comprehensive Guide to Toxicology in Preclinical Drug - download pdf or read online

By Ali S. Faqi (Auth.)

ISBN-10: 0123878152

ISBN-13: 9780123878151

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Additional info for A Comprehensive Guide to Toxicology in Preclinical Drug Development

Example text

This is because a sample withdrawn from the beaker for concentration analysis will yield a lower concentration, and thus, the ratio in Eqs. 8) becomes larger. This analogy is similar to what one encounters in vivo. After an IV infusion, drug distributes from the blood compartment to different tissues and organs in the body with different affinities. The relative concentration in the plasma may be quite low, or it may be higher if distribution is limited. For a small molecule, the volume of distribution may have no physical meaning for the reasons mentioned above, and thus, the resulting volume is sometimes called an apparent volume of distribution.

Rapid identification of drug metabolites with tandem mass spectrometry. Biological Mass Spectrometry 1998;15:193e204. [78] Yost RA, Brotherton HO, Perchalski RJ. Tandem mass spectrometry for studies of drug action and metabolism. Int J Mass Spectrom Ion Phys 1983;48:77e80. [79] Vrbanac JJ, O’Leary IA, Baczynskyj. Utility of the parent-neutral loss scan screening technique: partial characterization of urinary metabolites of U-78875 in monkey urine. Biological Mass Spectrometry 1992;21:517e22. [80] Zhu M, Zhang H, Humphreys WG.

99%, then the free fraction is small (1%). Rearranging Eq. 15) For the purpose of illustrating the effects of plasma protein binding on volume of distribution, assume that the compound does not sequester into red blood cells significantly, and that the red blood cell compartment can be ignored, or combined with the tissue compartment(s). 16) Next, incorporating Eq. 15) into Eq. 17) Thus, this relationship demonstrates that extensive plasma or tissue protein binding can affect the apparent volume of distribution.

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A Comprehensive Guide to Toxicology in Preclinical Drug Development by Ali S. Faqi (Auth.)

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